Madison Edwards and Caroline Walker each had a pair of hits for the Eagles on Sunday.
Katie Cleary had her second pinch hit RBI single in as many weeks.
Southern Miss will play in Sunday's consolation game on Sunday against Appalachian State.
The win over FSU was the first road victory over a ranked opponent since 2010.
The Golden Eagles travel to nationally-ranked Florida State and the Renegade Classic next weekend.
As a Freshman at Mesa CC in 2011: Hit .386 with 22 hits, a double and five RBI ... Appeared in 33 games with 57 at-bats ... Played for current co-head coach Jon Malgradi ... Had a .413 on-base percentage with four walks and two sacrifices
High School: Was a four-year letterwinner for coach Jeep Ray at Corona Del Sol High ... Batted .393 during her senior campaign with 46 hits and was 9-for-9 in stolen bases ... A three-time scholar-athlete and all-city second baseman during her final year
Travel Ball: Played with teammate Janae Martin on the Outlaws Gold squad during the 2008-2009 year ... Spent the 2007-2008 season on the Killer Bees and with the Lil'Saints from 2006-2007
Personal: Daughter of Brad and Kime Edwards ... Mother played softball at Colorado Northwestern ... Majoring in psychology
Edwards' Career Highs
Hits: 2 vs. Alcorn State (4/24/12)
Runs: 1, 8 times
RBI: 1, 4 times